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. 2022 Jun 1;13:918550. doi: 10.3389/fimmu.2022.918550

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Copyright © 2022 Xie, Li, Meng, Xu, Yang, Dong, He and Hu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interaction between KIRs of human maternal uNK cells and HLA-C of fetal trophoblast cells. The interaction of the mother’s two KIR genotypes (A/A, A/B) and the embryo’s three possible HLA-C genotypes (C1/C1, C1/C2, C2/C2) was analyzed. The C2 gene in the figure was at least one from the father. KIR A haplotypes mainly feature inhibiting receptors, including KIR2DL1and KIR2DL3. The KIR B haplotypes mainly include KIR2DL1, KIR2DL2, and activating receptor KIR2DS1.