. Author manuscript; available in PMC: 2022 Sep 1.

Published in final edited form as: Ethics Hum Res. 2021 Sep;43(5):2–17. doi: 10.1002/eahr.500100

Table 4:

Main Factors Impacting Decision-Making to Approve Research Vignettes for Majority of IRB Members

Issues considered “a lot”	IRB members selecting this issue (n = 93)
Issues considered “a lot”	Observational study	Survey study	PK study
The risks of research participation for the fetus or pregnant woman are truly minimal	80 (86.0 %)	76 (81.7%)	71 (76.3%)
All kinds of people with the condition should be included to best understand the condition	71 (76.3%)	67 (72.0%)	n/a^*
Access to research should not discriminate against pregnant women	64 (68.8%)	62 (66.7%)	62 (66.7%)
Certain conditions can affect pregnant women and should be studied	62 (66.7%)	65 (69.9%)	n/a^*
Efforts should be made to fill research gaps on conditions that affect pregnant women	48 (51.6%)	53 (57.0%)	70 (76.1%)
This treatment is already widely being used and should be studied	n/a^*	n/a^*	83 (89.2%)
Important biomedical knowledge cannot be obtained without pregnant women	n/a^*	n/a^*	80 (86.0%)
All populations at risk for HIV need accurate PK data on available treatments	n/a^*	n/a^*	67 (72.0%)

n/a = issue was not a selection option