TABLE 1.

Depletion kinetics of THC and 11-OH-THC in pooled human intestinal microsomes.

Data presented are mean ± S.D. of independent experiments (n = 3–5), each conducted in duplicate or triplicate. CL_int was calculated as depletion CL/f_u,inc.

	THC				11-OH-THC
	Vmax (nmol/min/mg)	Km (nM)	CLinta (ml/min/mg)	Fm	CLint (ml/min/mg)	Fm
CYP2C9	1.1 ± 0.38	70 (fixed)	15 ± 5.4	0.89 ± 0.31	NS	NS
CYP3A	NA	NA	2.0 ± 0.86	0.11 ± 0.050	0.26 ± 0.058	0.51 ± 0.11
Total P450	NA	NA	17 ± 6.0	1.0 ± 0.32	0.34 ± 0.080	0.67 ± 0.16
UGT2B7	NA	NA	NS	NS	0.13 ± 0.027	0.25 ± 0.053
Total UGT	NA	NA	NS	NS	0.17 ± 0.024	0.33 ± 0.046

NA, not applicable; NS, not significant.

^aWhen CYP2C9 was not saturated.