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Depletion kinetics of THC and 11-OH-THC in pooled human fetal liver microsomes.
Data presented are mean ± S.D. of four independent experiments. CLint was calculated as depletion CL/fu,inc.
| THC | 11-OH-THC | |||
|---|---|---|---|---|
| CLint (ml/min/mg) | Fm | CLint (ml/min/mg) | Fm | |
| CYP3A | 4.6 ± 0.17 | 0.99 ± 0.06 | 1.9 ± 0.11 | 0.80 ± 0.06 |
| Total P450 | 4.7 ± 0.22 | 1 | 2.4 ± 0.13 | 1 |
