Fig. 5.

Lupus-like syndrome is attenuated in lupus mice by overexpression of CD81. A Representative photographs of the spleen from control groups, IMQ groups, IMQ + vector groups and IMQ + AAV-CD81 groups (n = 4 mice/group). B H&E and PAS staining of kidney sections in each group (scale bar = 50 μm). (n = 4 mice/group). C, D The levels of serum anti-dsDNA, IgG and IgM (C) and urine protein (D) were detected by ELISA from control groups, IMQ groups, IMQ + vector groups and IMQ + AAV-CD81 groups (n = 4 mice/group). E, F The proportions of Th17 and Treg cells in blood (E) and spleen (F) were determined by FACS (n = 6 mice/group). Data are presented the mean ± standard error of the mean (SEM). *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001