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Metformin inhibits melanoma cells metastasis in vivo. A, B Metformin suppressed pulmonary metastasis. Pretreatment of metformin inhibited melanoma cell metastasis to lung more effectively. n = 5. The black dots on the surface of the lungs indicate metastasis foci. *p < 0.05, **p < 0.01, ***p < 0.001 versus control
