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. 2022 Jun 15;19:150. doi: 10.1186/s12974-022-02483-1

Fig. 6.

Fig. 6

Resistance training modulated different myokines and intracellular signal pathways in the brain following surgery. ac Relative mRNA levels of FGF-21, PGC-1α and IL-6 in the hippocampus, muscle and liver. df Representative blots and quantitative analysis of key proteins in intracellular signal transduction in the hippocampus on postoperative day 1 and (gi) day 14, respectively. The intensity of band of BDNF, Akt, GSK3β, Bax and Bcl-2 was normalized to GAPDH. Data were analyzed by two-way ANOVA, followed by Tukey multiple comparisons test, n = 6. Data presented as mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001