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. 2022 Jun 15;23:443. doi: 10.1186/s12864-022-08593-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Analysis of differentially expressed genes (DEG) in embryos according to maternal age. A representation of down (blue) and upregulated (red) DEG in ICM (from DeMixT_ICM_cells data obtained after deconvolution of ICMandTE using DeMixT R package [38, 39]) and TE (from TE_part dataset) of embryos from OM. Nota bene: YM is the reference group. Functional classifications (for down regulated genes in ICM and TE and for up-regulated genes in ICM) using GO Biological Process obtained with PANTHER online software are presented as pie charts. For upregulated DEG in TE, no functional classification was made. B Bar chart presenting p-adjusted of most specific subclass pathways provided by PANTHER online software after statistical overrepresentation test (Fisher’s Exact test and Benjamini-Hochberg correction) with the Human GO Biological Process annotation on down-regulated DEGs in ICM of OM. Nota bene: YM is the reference group. DEG: Differentially Expressed Genes (FDR < 0.05); TE: Trophoblast; ICM: Inner Cell Mass; OM: Old mares; YM: young mares