Table 2.
Mean ± standard deviation values of cardiorespiratory parameters, in dogs treated with ketamine (GK: bolus 0.5 mg kg−1; CRI 20 µg kg−1 min−1 in intra- and postoperative periods), fentanyl (GF: bolus 5 µg kg−1; intraoperative CRI 5 µg kg−1 h−1 and postoperative CRI 2 µg kg−1 h−1), or combination of ketamine-fentanyl (GKF: aforementioned doses) in postoperative period
| Postoperative period (hours) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable | Group | Baseline | 0.25 | 0.5 | 1 | 2 | 4 | 6 | 8 | 12 |
|
HR (beats minute−1) |
GK | 104 ± 13 | 107 ± 14a | 96 ± 20 | 87 ± 10a# | 95 ± 14a | 86 ± 13 | 86 ± 13 | 98 ± 39 | 101 ± 14 |
| GKF | 110 ± 22 | 104 ± 13a | 97 ± 9 | 89 ± 7a | 87 ± 14a.b# | 90 ± 13 | 90 ± 7 | 95 ± 14 | 94 ± 16 | |
| GF | 97 ± 35 | 82 ± 24b | 71 ± 13 | 70 ± 20b# | 75 ± 21# | 65 ± 17# | 79 ± 14 | 83 ± 18 | 83 ± 17 | |
|
fR (breaths minute−1) |
GK | 30 ± 10 | 40 ± 23 | 36 ± 15 | 43 ± 12# | 47 ± 11# | 37 ± 18 | 32 ± 10 | 30 ± 10 | 43 ± 47 |
| GKF | 34 ± 14 | 44 ± 41 | 39 ± 23 | 45 ± 23 | 52 ± 39 | 35 ± 13 | 36 ± 11 | 29 ± 10 | 35 ± 15 | |
| GF | 28 ± 4 | 54 ± 21 | 44 ± 25 | 68 ± 37 | 43 ± 27 | 29 ± 17 | 33 ± 20 | 38 ± 19 | 27 ± 7 | |
|
SAP mmHg |
GK | 136 ± 25 | 137 ± 9a.b | 139 ± 12 | 136 ± 15 | 136 ± 24 | 148 ± 17 | 144 ± 17 | 140 ± 22 | 143 ± 16 |
| GKF | 153 ± 13 | 153 ± 15a | 155 ± 18 | 151 ± 17 | 170 ± 28 | 160 ± 15 | 160 ± 21 | 151 ± 12 | 143 ± 21 | |
| GF | 136 ± 13 | 132 ± 23b | 163 ± 12 | 148 ± 8 | 138 ± 35 | 136 ± 15 | 141 ± 10 | 158 ± 7# | 147 ± 3 | |
a, b, c Significant difference between group. # Significant difference in treatment with a basal time point. HR Heart rate, fR respiratory rate, SAP systolic arterial pressure