Table 3.
Mean ± standard deviation values of arterial blood gas analyses in dogs treated with ketamine (GK: bolus 0.5 mg kg−1; CRI 20 µg kg−1 min−1 in intra- and postoperative periods), fentanyl (GF: bolus 5 µg kg−1; intraoperative CRI 5 µg kg−1 h−1 and postoperative CRI 2 µg kg−1 h−1), or combination of ketamine-fentanyl (GKF: aforementioned doses) in intraoperative and postoperative period
| Anesthesia (minutes) | Postoperative (hours) | |||||||
|---|---|---|---|---|---|---|---|---|
| Variable | Group | 20 | 40 | 60 | 80 | 1 | 4 | 8 |
| pH | GK | 7.30 ± 0.08 | 7.29 ± 0.07 | 7.29 ± 0.06 | 7.31 ± 0.06 | 7.33 ± 0.04 | 7.39 ± 0.02 | 7.38 ± 0.04 |
| GKF | 7.36 ± 0.06 | 7.33 ± 0.06 | 7.31 ± 0.05 | 7.27 ± 0.04# | 7.34 ± 0.02 | 7.38 ± 0.03 | 7.41 ± 0.01 | |
| GF | 7.29 ± 0.08 | 7.27 ± 0.04# | 7.27 ± 0.03# | 7.25 ± 0.02# | 7.33 ± 0.01 | 7.37 ± 0.02 | 7.41 ± 0.01 | |
|
PaO2 (mmHg) |
GK | 294.6 ± 89.2 | 319.8 ± 80.2 | 304.4 ± 88.0 | 293.5 ± 4.4 | 80.4 ± 3.0 | 90.8 ± 13.9 | 83.7 ± 7.9 |
| GKF | 300.9 ± 62.3 | 328.1 ± 106.2 | 296.2 ± 89.8 | 290.3 ± 89.8 | 78.2 ± 6.6 | 79.4 ± 5.6 | 80.7 ± 6.3 | |
| GF | 291.5 ± 4.07 | 274.2 ± 36.1 | 266.5 ± 29.0 | 282.7 ± 88.9 | 80.8 ± 3.1# | 84.3 ± 5.0# | 84.2 ± 5.4# | |
| PaCO2 (mmHg) | GK | 45.9 ± 11.2 | 46.4 ± 10.2 | 45.2 ± 8.5 | 42.9 ± 6.3 | 40.9 ± 4.2 | 31.4 ± 1.7 | 32.3 ± 1.5 |
| GKF | 38.7 ± 6.1 | 40.6 ± 6.9 | 43.0 ± 5.8 | 48.5 ± 8.5# | 43.3 ± 4.3 | 36.3 ± 2.0 | 33.1 ± 2.1 | |
| GF | 44.2 ± 15.3 | 44.6 ± 8.8 | 43.3 ± 6.9 | 46.8 ± 5.3 | 41.5 ± 2.2 | 34.3 ± 3.9 | 35.3 ± 1.1 | |
| HCO3− (mmol L−1) | GK | 21.8 ± 1.8 | 21.3 ± 1.3 | 20.8 ± 1.5 | 20.9 ± 0.8 | 21.1 ± 2.0 | 18.6 ± 0.4 | 18.6 ± 0.7 |
| GKF | 21.0 ± 0.5 | 20.9 ± 0.7 | 20.8 ± 0.8 | 21.8 ± 1.7 | 23.2 ± 1.2 | 21.1 ± 1.2 | 20.3 ± 1.2 | |
| GF | 7.30 ± 0.08 | 20.8 ± 3.0 | 20.1 ± 2.5 | 20.6 ± 2.4 | 21.0 ± 0.7 | 19.7 ± 2.6 | 21.2 ± 0.3 | |
# Significant difference in treatment with a basal time point. pH; arterial partial pressure of oxygen (PaCO2); arterial partial pressure of carbon dioxide (PaCO2); arterial bicarbonate (HCO3−)