Table 2.

Factors related to tolerability in intensive blood pressure control

Factor	Clinical features
Functional status or physical fitness	Frailty, disability
Symptomatic aspects	Weakness, dizziness, fatigue
Diagnostic aspects	Standardized office blood pressure measurement Exclusion of orthostatic hypotension: orthostatic blood pressure measurement Assessment of white-coat effect or masked effect Application of home or ambulatory blood pressure monitoring
Hemodynamic aspects	Orthostatic hypotension Volume depletion or poor oral intake Presence of vascular stenosis in coronary, renal, and/or cerebral arteries
Related clinical event history	Injurious fall Acute kidney injury Electrolytes abnormalities
Speed of up-titration	Large pulse pressure Frail patients