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. 2022 Jun 15;24:143. doi: 10.1186/s13075-022-02827-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — A–C Clinical outcome of CTLA4-Ig treatment in RA patients. A DAS value across 12 months of follow-up of CTLA4-Ig treatment in RA patients (whole cohort, cohort 1, and cohort 2, respectively); p values were calculated using Wilcoxon matched-pairs signed rank test comparing DAS at pre-treatment and after 3, 6, and 12 months of CTLA4-Ig administration in RA patients (whole RA cohort, RA cohort 1, or RA cohort 2). B CDAI value across 12 months of follow-up of CTLA4-Ig treatment in RA patients (whole cohort, cohort 1, and cohort 2, respectively); p values were calculated using Wilcoxon matched-pairs signed rank test comparing CDAI at pre-treatment and after 3, 6, and 12 months of CTLA4-Ig administration in RA patients (whole RA cohort, RA cohort 1, or RA cohort 2). C Kaplan–Meier survival curve of treatment with CTLA4-Ig across 12 months of follow-up in RA patients (whole cohort, cohort 1, and cohort 2, respectively) for DAS (log-rank test: chi-square = 0.029 p = 0.863; Breslow test: chi-square = 0.346 p = 0.841) and CDAI (log-rank test: chi-square = 0.217 p = 0.641; Breslow test: chi-square = 0.823 p = 0.663). DAS, Disease Activity Score; CDAI, Composite Disease Activity Index; RA, rheumatoid arthritis