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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: FEBS Lett. 2021 Nov 19;596(1):17–28. doi: 10.1002/1873-3468.14228

Fig. 3.

Fig. 3.

Sildenafil regulation of mitochondrial function in PGC1α+/+ and PGC1α−/− TAC hearts. (A) Mitochondrial respiration in cardiac muscle fibers using palmitoyl-L-carnitine, glutamate or pyruvate as substrate in PGC1α+/+ and PGC1α−/− TAC hearts after sildenafil treatment (SIL) (n = 4–5 per group). Groups were compared by 2-way ANOVA followed by Tukey-Kramer post-hoc test. (B) Myocardial PGC1α expression in TAC hearts after sildenafil or vehicle treatment (n = 7–8 per group). Groups were compared by 2-way ANOVA followed by Tukey-Kramer post-hoc test. *P < 0.05; **P < 0.01; ***P < 0.001.