Table 4B.
Intrinsic connectivity network biomarkers predicting antidepressant response to glutamatergic interventions.
| Glutamatergic compound | Reference | DMN | AN | RN | CEN | SN | SMN | CAN |
|---|---|---|---|---|---|---|---|---|
| Ketamine | Abdallah et al. (131) | ↑ left MTL | ↑ left INS | ↑ bilateral CN | ↑ bilateral DLPFC | ↑ left AI | ↑ bilateral CN | ↑ left INS |
| Abdallah et al. (132) | – | ↑ VMPFC | ↑ VMPFC | – | – | – | – | |
| Abdallah et al. (133) | – | ↓ VMPFC | ↓ VMPFC | ↑ DLPFC | – | – | – | |
| Carlson et al. (134) | ↑right _ _ _LTL _ _↓right _ _ _ _MTL_ ↓ left _ _IPL |
↓right _ _ _ _HPC _ ↓ vACC |
– | – | – | ↑left _ _ _ _CBM | – | |
| Chen et al. (135) | – | ↓ right vACC/sgACC ↔ left dACC (suicidal ideation) | – | ↑ right DLPFC ↔ left SPL (suicidal ideation) | ↓ left dACC ↔ right vACC/sgACC (suicidal ideation) | – | – | |
| Chen et al. (136) | – | – | ↓ executive BG ↔ superior frontal gyrus | ↓ superior frontal gyrus ↔ executive BG | – | ↓ executive BG ↔ superior frontal gyrus | – | |
| Downey et al. (137) | ↑rACC | ↑sgACC | – | – | ↑dACC | – | – | |
| Evans et al. (138) | – | – | – | – | – | – | – | |
| Gärtner et al. (139) | – | ↑ sgACC ↔ right DLPFC | – | ↑ right DLPFC ↔ sgACC | – | – | – | |
| Gilbert et al. (140) | – | ↓INS ↔ ACC | – | – | ↓AI ↔ dACC | – | ↓INS ↔ ACC | |
| Kraus et al. (141) | – | – | – | – | – | – | – | |
| Lally et al. (142) | – | ↑right _ _ _ _HPC _ _ _ _ _ _ _ _(anhedonia) _ ↓ right _ _ _ _mOFC _ _ _ _ _ _ _ _(anhedonia) |
↓right _ _ _ _ _mOFC _ _ _ _ _ _ _ _(anhedonia) | – | ↑dACC _ _ _ _ _ _ _ _(anhedonia) | – | – | |
| Li et al. (143) | – | – | – | – | – | – | – | |
| Loureiro et al. (144) | – | ↓right AMYG (anhedonia)
↑right INS |
– | ↑right DLPFC (fearful cue)
↓right DLPFC (happy cue; anhedonia) |
↑right AI | – | ↓right AMYG (anhedonia)
↑right INS |
|
| Loureiro et al. (145) | – | – | – | ↓ CEN ↔ CBM | – |
↓ CBM ↔ CEN
↓ CBM ↔ SMN |
– | |
| McMillan et al. (146) | – | – | ↑right INS | – | – | ↓S1 | ↑right INS | |
| Mkrtchian et al. (147) | – | – | ↑dorsal CN ↔ right ventrolateral PFC (anhedonia)
↑ dorsal CN ↔ pgACC (anhedonia) |
– | – | ↑dorsal CN ↔ right ventrolateral PFC (anhedonia)
↑ dorsal CN ↔ pgACC (anhedonia) |
– | |
| Morris et al. (148) | – | ↑sgACC (anhedonia) | – | – | – | – | – | |
| Murrough et al. (149) | ↑DMN ↔ right CN | ↑AN ↔ right CN | ↑right CN ↔ ACC | – | – | ↑right CN ↔ ACC | – | |
| Nakamura et al. (150) | – | ↓ right sgACC ↔ right AMYG | – | – | – | – | ↓ right AMYG ↔ right sgACC | |
| Nemati et al. (151) | ↓DMN ↔ SMN | – |
↓ GPu SC within
↑ GPu SC ↔ rest of brain |
↓within-network
↑ with rest of brain |
↓ SN ↔ SMN | ↓within-network
↓ GPu SC within ↑ GPu SC ↔ rest of brain ↓SMN ↔ SN ↓SMN ↔ DMN |
– | |
| Nugent et al. (152) | – | – | – | – | – | – | – | |
| Reed et al. (153) | ↓PCu (angry cue)
↑PCu (happy cue) |
↓AMYG (angry cue)
↓left parahippocampal gyrus (angry cue) ↑AMYG (happy cue) ↑left parahippocampal gyrus (happy cue) |
– | ↑DLPFC (happy cue)
↓DLPFC (angry cue) |
↑dACC (happy cue)
↓dACC (angry cue) |
– | ↓AMYG (angry cue) ↑AMYG (happy cue) |
|
| Reed et al. (154) | – | – | – | – | – | – | – | |
| Roy et al. (155) | – | – | ↑ right NAc | – | – | – | – | |
| Sahib et al. (156) | – | – | – | – | – | – | – | |
| Sahib et al. (157) | – | – | – | ↓within-network | – | ↓SMA | – | |
| Sahib et al. (158) | – | – | ↑BG ↔ CBM | – | ↑SN ↔ CBM | ↑BG ↔ CBM ↑CBM ↔ SN |
– | |
| Salvadore et al. (159) | ↑rACC | ↓right AMYG | – | – | – | – | ↓right AMYG | |
| Salvadore et al. (160) | – | ↓left AMYG ↔ pgACC | – | – | – | – | ↓left AMYG ↔ pgACC | |
| Siegel et al. (161) | ↓ within-network | – | – | – | – | – | – | |
| Sterpenich et al. (162) | – | ↑mOFC | ↑mOFC
↑ventral striatum ↑ VTA/SNc |
– | – | ↑ventral striatum
↑ VTA/SNc |
– | |
| Thai et al. (163) | ↓PCC/PCu | ↓left and right HPC/left and right AMYG/ACC ↑right HPC (congruent positive) | ↓left and right NAc | – | – | – | ↓left and right HPC/left and right AMYG/ACC | |
| Tiger et al. (164) | – | – | ↓ ventral striatum* | – | – | ↓ ventral striatum* | – | |
| Vasavada et al. (165) | – | ↑ right HPC ↔ left CEN (anhedonia) | – | ↑ left CEN ↔ right HPC (anhedonia) | – | – | – | |
| Wang et al. (166) |
↓ left PCu ↔ left LHb
↓ left PCu ↔ right LHb ↓ bilateral angular gyrus ↔ right LHb |
– |
↓ left LHb ↔ left PCu
↓ right LHb ↔ left PCu ↓ right LHb ↔ bilateral angular gyrus |
– | – | – | – | |
| Memantine | Kilpatrick et al. (167) | ↑ within-network | – | – | – | – | – | – |
| D-cycloserine | Cole et al. (168) | – | – | – | – | – | – | – |
| Nitrous oxide | – | – | – | – | – | – | – | – |
| 4-chlorokynurenine | Park et al. (169) | – | – | – | – | – | – | – |
| Lanicemine | Abdallah et al. (133) | – | – | – | ↑ DLPFC | – | – | – |
| Downey et al. (137) | ↑rACC | ↑sgACC | – | – | ↑dACC | – | – |
ACC, anterior cingulate cortex; AI, anterior insula; AN, ventromedial affective network; BG, basal ganglia; CAN, frontovagal central autonomic network; CBM, cerebellum; CEN, frontoparietal central executive network; CN, caudate nucleus; dACC, dorsal anterior cingulate cortex; DLPFC, dorsolateral prefrontal cortex; DMN, default mode network; GPu SC, globus pallidus-putamen subcortical; HPC, hippocampus; INS, insula; IPL, inferior parietal lobule; LHb, lateral habenula; LTL, lateral temporal lobe; MTL, medial temporal lobe; NAc, nucleus accumbens; PCu, precuneus; pgACC, pregenual anterior cingulate cortex; rACC, rostral anterior cingulate cortex; RN, ventral frontostriatal reward network; S1, primary somatosensory cortex; sgACC, subgenual anterior cingulate cortex; SMA, supplementary motor area; SMN, frontocerebellar sensorimotor network; SN, anterior cinguloinsular salience network; SNc, substantia nigra pars compacta; SPL, superior parietal lobule; vACC, ventral anterior cingulate cortex; VMPFC, ventromedial prefrontal cortex; VTA, ventral tegmental area.
Asterisks, serotonin (5-HT1B) receptor binding; bold, blood-oxygen-level-dependent (BOLD) response; bold underlined, magnetoencephalographic (MEG) activity; dotted underline, glucose metabolism; double underline, entropy; italics, functional connectivity; italics underlined, magnetoencephalographic (MEG) connectivity; no formatting, global brain connectivity (GBC). ↑, increased; ↓, decreased; ↔, functional connectivity between two brain regions.