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. 2022 Jun 1;13:781003. doi: 10.3389/fimmu.2022.781003

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Copyright © 2022 Shi, Li, Liu, Yin, Xiao, Fu, Zhu, Chen, Wang, Xiao, Zhang, Tan and Tan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HSF1 ameliorates pulmonary inflammation in sepsis-induced ALI. (A) The survival rate of HSF1^−/− and HSF1^+/+ mice after CLP. (B) After 12- and 24-h CLP interventions, representative pictures of lung tissue sections were stained with H&E. (C–F) The expression of IL-1β and lL-18 in lung homogenate and lung BALF after CLP operation was monitored by ELISA. Data are representative or means (SD) of at least three independent experiments. Statistical analyses were determined using a Student’s t-test and one-way ANOVA. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 versus control group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 versus HSF1^+/+ CLP group. ALI, acute lung injury; CLP, cecal ligation and puncture; BALF, bronchoalveolar lavage fluid.