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. 2022 Jun 1;13:877807. doi: 10.3389/fendo.2022.877807

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Copyright © 2022 Wang, Mu, Zhang, Long, Zhang, Li, Zhao and Qiao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Abnormal activation of tryptophan-kynurenine pathway in PCOS. (A) The plasma level changes of metabolites in tryptophan-kynurenine pathway in PCOS patients compared with control groups, ***p < 0.001; **p < 0.01; *p < 0.05; NS, not significant. (B) The sketch Map of changes of metabolites and key enzymes in tryptophan-kynurenine pathway in PCOS patients. The red color indicates increased metabolism and activated enzymes, the blue color indicates decreased metabolism, and the grey color indicates that the change trend of this pathway was not yet clear. (C) Correlation analysis of differential metabolites levels with the endocrine and metabolic parameters in all subjects. TRP, tryptophan; 5-HT, serotonin; KYN, kynurenine; KYNA, kynurenic acid; QA, quinolinic acid.