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. 2022 Jun 1;13:877807. doi: 10.3389/fendo.2022.877807

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Copyright © 2022 Wang, Mu, Zhang, Long, Zhang, Li, Zhao and Qiao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of metabolites in tryptophan-kynurenine pathway associated with PCOS. (A) Unadjusted odds ratios (95% CIs) of PCOS per 1 SD change in plasma abundance of each metabolite. (B) The odds ratios (95% CIs) of PCOS per 1 SD increase in plasma abundance of each metabolite adjusted for baseline age, BMI, LH, androstenedione, and AMH. (C, D) Concentration-effect relationship of metabolites in tryptophan-kynurenine pathway associated with PCOS. The prevalence of PCOS was dramatically raised with the quartiles of TRP, tryptophan; KYN, kynurenine; KYNA,kynurenic acid and QA, quinolinic acid while decreased with quartiles of KYN/KYNA, before (C) and after (D) adjusting for baseline age, BMI, LH, androstenedione and AMH.