Table 2.
Operative and post-operative characteristics.
| Variable | Alemtuzumab | Basiliximab | P value | Odds Ratio | 95% CI |
|---|---|---|---|---|---|
| n = 453 | n = 354 | ||||
| Lung transplant procedure | |||||
| Single | 58 (12.8) | 48 (13.6) | 0.75 | 0.94 | 0.62-1.41 |
| Bilateral | 395 (87.2) | 306 (86.4) | |||
| Intraoperative support | |||||
| None | 179 (39.5) | 136 (38.4) | 0.48 | - | - |
| Cardiopulmonary bypass | 140 (30.9) | 123 (34.7) | |||
| ECMO | 134 (29.6) | 95 (26.8) | |||
| Total ischemic time, Median (IQR) | 393.0 (335.5-466.5) | 401.0 (342.0-458.0) | 0.49 | - | - |
| Operative time (hours:mins), Median (IQR) | 8:02 (6:49-9:33) | 8:10 (6:53-9:33) | 0.54 | - | - |
| Intraoperative blood transfusion, Median (IQR) [mL] | 900.0 (300.0-1500.0) | 900.0 (107.5-1800.0) | 0.66 | - | - |
| Delayed Chest Closure | 112 (24.7) | 111 (31.4) | 0.037 | 1.39 | 1.02-1.90 |
| Any grade 3 primary graft dysfunction Within 72 Hours | 84 (19.9) | 94 (29.9) | 0.002 | 1.72 | 1.22-2.42 |
| Postoperative ECMO | 66 (14.6) | 70 (19.8) | 0.052 | 1.44 | 1.00-2.09 |
| Acute kidney injury requiring renal replacement therapy | 67 (14.8) | 63 (17.8) | 0.25 | 1.25 | 0.86-1.82 |
| Stroke | 16 (3.5) | 10 (2.8) | 0.57 | 0.79 | 0.36-1.77 |
| Re-intubation | 102 (22.5) | 67 (18.9) | 0.21 | 0.8 | 0.57-1.14 |
| Bowel ischemia requiring bowel resection | 17 (3.8) | 10 (2.8) | 0.47 | 0.75 | 0.34-1.65 |
| Postop Hepatic Dysfunction | 40 (8.8) | 52 (14.7) | 0.009 | 1.78 | 1.15-2.76 |
| Hemothorax | 54 (11.9) | 42 (11.9) | 0.98 | 1 | 0.65-1.53 |
| Total intensive care unit stay (days), Median (IQR) | 12.21 (4.0-19.0) | 9.00 (4.0-18.0) | 0.73 | - | - |
| Total vent duration (days), Median (IQR) | 3.88 (1.17-14.0) | 5.00 (1.99-12.0) | 0.38 | - | - |
| Acute cellular rejection in First Year | 177 (39.1) | 189 (53.4) | < 0.001 | 1.79 | 1.35-2.37 |
| Methylprednisolone (pulse dose) | 176 (38.9) | 149 (42.1) | 0.35 | 1.14 | 0.86-1.52 |
| Hydrocortisone (Stress dose) | 133 (29.4) | 90 (25.5) | 0.22 | 0.82 | 0.60-1.13 |
| Pneumonia | 163 (36.0) | 129 (36.4) | 0.89 | 1.02 | 0.76-1.36 |
| Wound Complication | 85 (18.8) | 72 (20.3) | 0.58 | 1.11 | 0.78–1.57 |
| Bronchiolitis obliterans syndrome | 90 (19.9) | 71 (23.5) | 0.95 | 1.01 | 0.72–1.43 |