TABLE 3.
Potentiator (Pot) factors: mutations increase β-lactam resistance
| Gene/operon | SAOUHSC | Functional class | Function | Reference(s) |
|---|---|---|---|---|
| clpXP | 01778/00790 | Protein stability | ATP-dependent Clp protease | 118 |
| gdpP | 00015 | Nucleotide signaling | Phosphodiesterase, hydrolyzes cyclic-di-AMP | 128 |
| pde2 | 01812 | Nucleotide signaling | Phosphodiesterase, hydrolyzes c-di-AMP and pApA to AMP | 129 |
| relA | 01742 | Nucleotide signaling | Bifunctional synthase and hydrolase of (p)ppGpp alarmone | 69 |
| rpoB/rpoC | 00524/5 | Genetic information processing | DNA-directed RNA polymerase β/β’ subunit | 50, 141 |
| agr | 02261–02265 | Quorum sensing | Global regulator of biofilm formation and toxin production | 149 |
| lytH | 01739 | Cell wall homeostasis | PG hydrolase | 155 |
| dlt operon | 00868–00872 | Cell wall homeostasis | Transfer of d-alanine onto teichoic acids | 152 |