. 2022 May 16;60(6):e00075-22. doi: 10.1128/jcm.00075-22

TABLE 1.

Diagnostic sensitivity^a

mpo	dpo	No. of samples	A₄₅₀-A₆₂₀ cutoff	No. of positive samples, % sensitivity (95% CI) for ELISA 1 (sera, 1:100)	No. of positive samples, % sensitivity (95% CI) for ELISA 2 (sera, 1:2)	P
<1	10–28	19	0.200	14, 73.7 (50.9–88.5)	19, 100.0 (80.2–100.0)	0.0463
<1	10–28	19	0.400	11, 57.9 (36.2–76.9)	17, 89.5 (67.4–98.3)	0.0625

1–2	29–56	21	0.200	19, 90.5 (69.9–98.5)	21, 100.0 (81.8–100.0)	0.4878
1–2	29–56	21	0.400	19, 90.5 (69.9–98.5)	20, 95.2 (75.6–100.0)	1.0000

2–5	57–140	34	0.200	28, 82.3 (66.1–92.0)	32, 94.1 (79.9–99.3)	0.2585
2–5	57–140	34	0.400	26, 76.5 (59.8–87.8)	31, 91.2 (76.3–97.7)	0.1863

5–8	141–224	27	0.200	17, 63.0 (44.2–78.5)	24, 88.9 (71.1–96.8)	0.0537
5–8	141–224	27	0.400	13, 48.1 (30.7–66.0)	23, 85.2 (66.9–94.7)	0.0084

8–12	225–336	24	0.200	8, 33.3 (17.8–53.4)	17, 70.8 (50.6–85.3)	0.0199
8–12	225–336	24	0.400	3, 12.5 (3.5–31.8)	16, 66.7 (46.6–82.2)	0.0003

12–15	337–396	17	0.200	5, 29.4 (13.0–53.4)	14, 82.3 (58.2–94.6)	0.0049
12–15	337–396	17	0.400	2, 11.8 (2.0–35.6)	14, 82.3 (58.2–94.6)	0.0001

Longitudinal serum samples obtained from 35 COVID-19 patients were stratified according to months postonset (mpo) (≤1 sample/patient/category). Sensitivities as well as 95% confidence intervals (CIs) were calculated for two alternative cutoff values (A₄₅₀-A₆₂₀ = 0.2 and 0.4). dpo, days postonset. P values were determined using Fisher’s exact test.