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. 2022 May 26;9:812846. doi: 10.3389/fnut.2022.812846

TABLE 1.

Characteristics of studies included in the systematic review owing to report the comparison of BMI between the lowest vs. the highest LTL categories.

First Author Country Journal Study Population Gender Age rTLT
assay
Num. Obesity/
overweight
Adjusted confounders Main finding
Linghui (37) China Fron Aging Neurosci Healthy Both 65–80 qPCR 2,006 Obesity Unadjusted Non-significant lower BMI in the highest vs. the lowest rTLT categories (P = 0.585)
Zgheib (38) Lebanon Aging and Disease Healthy Both > 18 qPCR 497 Central
obesity
Unadjusted BMI in the highest tertile of rLTL was significantly lower than the lowest (P = 0.045)
Milte (39) Australia Eur J Nutr Healthy Both 57–68 qPCR 679 Obesity Unadjusted Non-significant lower BMI in the highest vs. the lowest rTLT categories (P = 0.116)
Mazidi (40) United States Angiology Healthy Both > 18 qPCR 8,892 Obesity Age, race,
sex
Non-significant lower BMI in the highest vs. the lowest rTLT categories (P = 0.312)
Mwasongwe (41) United States Atherosclerosis Healthy Both > 21 qPCR 5,306 Obesity Age, sex Non-significant higher BMI in the highest vs. the lowest rTLT categories (P = 0.30)
Mazidi (42) United States Oncotarget Healthy Both > 18 qPCR 5,020 Obesity Unadjusted BMI in the highest rLTL quartile (26.4 ± 0.21) was significantly lower than the lowest (28.5 ± 0.18) P < 0.001
Julin (43) United States Eur J Nutr Healthy Men 40–75 qPCR 2,483 Obesity Age BMI in the highest rLTL quartile (25.8 ± 3.2) was significantly lower than the lowest (26.2 ± 3.5) P = 0.05
Hardikar (44) United States BMC Obesity Barrett’s esophagus Both 50–70 qPCR 295 Obesity Age, sex BMI in the highest rLTL quartile (29.1 ± 4.3) was significantly higher than the lowest (28.1 ± 3.6) P = 0.05
Zalli (45) United Kingdom PNAS Healthy Both 54–76 qPCR 333 Obesity Unadjusted No significant difference between the lowest vs. the highest rTLT categories
Chen (5) United States Aging Healthy Both 30–50 qPCR 3,256 Obesity Age BMI in the highest rLTL quartile (30.1 ± 7.6) was significantly lower than the lowest (33 ± 7.6) P < 0.001
Liu (46) United States Am J Epidemilo Healthy Both 30–55 qPCR 4,604 Obesity Age BMI in the highest rLTL quartile (25.4.1 ± 4.5) was significantly lower than the lowest (25.8 ± 5) P = 0.03
Cassidy (4) United States Am J Clin Nutr Healthy Women 30–55 qPCR 2,284 Obesity Age BMI in the highest rLTL quartile (25.3.1 ± 4.3) was significantly lower than the lowest (26 ± 4.9) P = 0.005