TABLE 2.
Characteristics of studies included in the systematic review owing to report the comparison of LTL between obese/overweight vs. non-obese/non-overweight individuals.
| First author | Country | Journal | Study population | Gender | Age | rTLT assay |
Num. | Obesity/overweight | Adjusted confounders | Main finding |
| Batsis (47) | United States | Int J Obes | Healthy | Both | > 18 | qPCR | 7,827 | Obesity + overweight | Stratification by age |
rTLT in overweight and obese individuals was significantly lower than those with normal weight (P < 0.001) |
| Zhao (48) | United States | Oncotarget | Healthy | Both | 20–85 | qPCR | 12,792 | Obesity + overweight | Age, gender | rTLT in obese was higher than overweight and normal weight individuals (P < 0.001) |
| Min (49) | United States | Eur J Nutr | Healthy | Both | > 20 | qPCR | 3,660 | Obesity + overweight | Age, gender, ethnicity, income, smoking, alcohol, BMI, history of diabetes | rTLT in obese and overweight individuals was significantly lower than normal weight individuals (P < 0.001) |
| Müezzinlera (50) | Germany | Exp Gerontol | Healthy | Both | 50–75 | qPCR | 3,600 | Obesity + overweight | Age | rTLT in obese and overweight individuals was non-significantly lower than normal weight individuals (P = 0.074) |
| Cui (52) | China | obesity | Healthy | Women | 40–70 | qPCR | 2,912 | Obesity | Age | Those with the highest BMI had significantly lower rTLT compared with others (P = 0.005) |
| Strandberg (53) | Finland | J Gerontol | Healthy | Men | 30–45 | qPCR | 480 | Obesity | Age | rTLT in obese and overweight individuals was non-significantly lower than normal weight individuals (P = 0.06 and 0.07 respectively) |
| Fitzpatrick (51) | United States | Med Sci | Healthy | Both | > 65 | qPCR | 1,136 | Obesity | Age | Non-significantly higher LTL in obese vs. non-obese individuals (P = 0.32) |
The results of each of the studies by Batsis JA et al. (47), Zhao H et al. (48), Min YB et al. (49), and Müezzinlera A (50) were included as two separate studies as overweight and obese individuals.
In addition, the study by Strandberg TE (54) was included as two independent studies of those in the age ranges of 30–45 years and those in the age range of 75–85 years. All of the included studies had cross-sectional designs.