Fig. (2).

HDACs and SIRTs mediated pathological mechanism of Alzheimer’s disease. Histone proteins present in nucleus accumbens and cortex causes mutation on ataxin 1 through chronic stress. Mutation on ataxin 1 causes misfolded DNA which further releases aβ fragments, result beta amyloid accumulation. On the other side, in the brain neuron, presence of HDAC causes ROS production which activates AMPK followed by SIRT1 activation. SIRT1 further increases the level of CREB and BDNF. Activation of Synapsin1 leads to beta amyloid accumulation and further causes Alzheirmer’s disease.