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. 2022 Jan 10;20(1):158–178. doi: 10.2174/1570159X19666210609160017

Fig. (3).

Fig. (3)

HDACs and SIRTs mediated pathological mechanism of Parkinson disease. Histone proteins present in nucleus accumbens and cortex causes activation of COX-1. Gene (ptgs1, Prostaglandin-Endoperoxide Synthase 1) causes neuroinflammation through NF-kβ signalling pathway.