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Role of ROS in the NF-κB mediated Alzheimer's pathogenesis. Abbreviation: ROS, reactive oxygen species; NF-κB, nuclear factor kappa B; APP, amyloid precursor protein; BACE1, beta-secretase 1. LOX, lypoxygenase; NOX, NADPH oxidase; iNOS, inducible nitric oxide synthase; COX2, cyclooxygenase 2; TNFα, tumor necrosis factor-α; IL-1, interleukin-1.
