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. Author manuscript; available in PMC: 2023 May 27.
Published in final edited form as: J Vis Exp. 2022 May 27;(183):10.3791/61504. doi: 10.3791/61504

Figure 2: Closed-head weight drop model of mild traumatic brain injury.

Figure 2:

(A) The anesthetized mouse is grasped by the tail and placed on a taut sacrificial membrane (KimWipe) underneath a guide tube. A 54 g weight is dropped from 1 m onto the dorsal aspect of the head. (B) Within ~1 ms post-impact, the mouse’s head has rapidly rotated about the neck as it breaks through the sacrificial membrane. (C) Within ~5 ms post-impact, the entire mouse has fallen and is hanging by its grasped tail.