Table 3:

Number, proportion (with 95% confidence intervals [CI]), and crude risk ratios (with 95% CIs) showing the association of adjunctive azithromycin versus placebo with the risk of secondary neonatal outcomes undergoing unscheduled cesarean deliveries by time of administration of study drug

Outcomes	After skin incision (Median 3mins, range 0-229mins) N=269		0-30mins pre-incision N= 1378		>30-60mins pre-incision N=270		>60mins pre-incision (Median 85mins, range 61-218mins) N=96		Interaction p-value
	Azithromycin n=135	Placebo (ref) * n=134	Azithromycin n=693	Placebo (ref) * n=685	Azithromycin n=140	Placebo (ref) * n=130	Azithromycin n=51	Placebo (ref) * n=45
Composite neonatal outcome N=281	26 (19.3) [12.8-27.9]	27 (20.1) [13.5-28.9]	95 (13.7) [11.0-16.9]	86 (12.6) [10.0-15.7]	19 (13.6) [8.3-21.3]	14 (10.8) [6.1-18.4]	6 (11.8) [5.0-25.4]	8 (17.8) [8.5-33.6]	0.75
	0.96 (0.59-1.55)		1.10 (0.83-1.43)		1.26 (0.66-2.41)		0.66 (0.25-1.76)
Suspected or confirmed neonatal sepsis N=246	21 (15.6) [9.8-23.8]	24 (17.9) [11.7-26.5]	76 (11.0) [8.6-13.9]	79 (11.5) [9.1-14.6]	18 (12.9) [7.8-20.5]	14 (10.8) [6.1-18.4]	6 (11.8) [5.0-25.4]	8 (17.8) [8.5-33.6]	0.82
	0.87 (0.51-1.48)		0.95 (0.71-1.28)		1.19 (0.62-2.30)		0.66 (0.25-1.76)
NICU admission (>72 hr) N=262	26 (19.3) [12.8-27.9]	26 (19.4) [12.9-28.1]	80 (11.5) [9.1-14.5]	96(14.0) [11.3-17.3]	17 (12.1) [7.2-19.7]	10 (7.7) [3.9-14.6]	4 (7.8) [2.7-20.5]	3 (6.7) [2.0-20.0]	0.41
	0.99 (0.61-1.62)		0.82 (0.62-1.09)		1.58 (0.75-3.32)		1.18 (0.28-4.98)

^*(ref)- Reference group

^†Numbers in brackets are 95% confidence intervals for the proportions

^‡Composite neonatal outcome included neonatal death, neonatal sepsis, other serious neonatal complications: necrotizing enterocolitis, respiratory distress syndrome, periventricular leukomalacia, grade 3 or higher intraventricular hemorrhage and neonatal ICU admission greater than 72 hours.