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Schematic of the Reduced Uterine Perfusion Pressure (RUPP) model
The RUPP model is made by clipping the ovarian arteries and abdominal aorta with silver clips during the 3rd trimester in rats or in mice. Pregnant RUPP animals develop hypertension, decreased glomerular filtration rate, variable degrees of proteinuria, and fetal growth restriction. (Illustration credit: Ben Smith)
