Fig 2:

Angiotensin II model of Pregnancy-Associated Hypertension (PAH)

Female human angiotensinogen (hAogen) transgenic mice mated with male human renin (hRen) transgenic mice develop severe hypertension during pregnancy as human renin made from the fetus/placenta acts on maternal human angiotensinogen to induce excess angiotensin II that occurs only during pregnancy. Endogenous mouse renin will not cleave human angiotensinogen, making this a valuable model to study PAH. The opposite crosses (female hRen x male hAogen) can serve as controls as human angiotensinogen made in the fetus does not cross to the maternal circulation. (Illustration credit: Ben Smith)