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Posttranslational modifications of PGC‐1α: 1) PGC-1α activity can be activated via methylation by protein arginine methyltransferase1 (PRMT1), phosphorylated by p38 mitogen-activated protein kinase (MAPK) and AMP-activated protein kinase (AMPK), deacetylation by Sirtuin-1 (SIRT1). 2) PGC-1α activity can be inhibited via acetylation by general control of amino acid synthesis 5 (GCN5), phosphorylation by Akt, S6 Kinase, or glycogen synthase kinase 3β (GSK3β).
