TABLE 1.

Relationship between RNF146 expression and clinicopathologic parameters of patients with hepatocellular carcinoma.

Clinicopathologic Parameters		n = 80	RNF146		p
			Low Expression (n = 22)	High Expression (n = 58)
Age (years)	<50	33	10	23	0.638
	≥50	47	12	35
Sex	Male	67	18	49	0.773
	Female	13	4	9
HBV infection	No	13	5	8	0.333
	Yes	67	17	50
Serum AFP level (ng/ml)	<20	14	6	8	0.157
	≥20	66	16	50
Tumor size (cm)	<5	29	12	17	0.036 a
	≥5	51	10	41
No. of tumor nodules	1	65	20	45	0.173
	≥2	15	2	13
Cirrhosis	No	12	5	7	0.233
	Yes	68	17	51
Venous infiltration	No	44	17	27	0.014 a
	Yes	36	5	31
Tumor differentiation	I + II	53	16	37	0.451
	III + IV	27	6	21
TNM stage	I	32	12	20	0.102
	II + III	48	10	38
BCLC stage	0 + A	59	19	40	0.114
	B + C	21	3	18

HBV, hepatitis B virus; AFP, alpha-fetoprotein; TNM, tumor-node-metastasis; BCLC, Barcelona Clinic Liver Cancer.

^aStatistically significant.