TABLE 2.
Summary of total plasma and brain PK parameters for 30 mg IR trazodone following single and multiple oral doses and 300 mg OAD trazodone following multiple oral doses
| Dose/formulation | Dosing frequency | Cmax (ng/ml) | Tmax (h) | AUC a (ng/ml × h) |
|---|---|---|---|---|
| Plasma | ||||
| 30 mg IR | s.d. | 442 (17%) | 0.50 | 4992 (36%) |
| q.d. | 533 (21%) | 0.50 | 4992 (40%) | |
| 300 mg OAD | q.d. | 1632 (38%) | 5.18 | 26651 (46%) |
| Brain | ||||
| 30 mg IR | s.d. | 702 (18%) | 0.72 | 7841 (39%) |
| q.d. | 860 (23%) | 0.65 | 8610 (41%) | |
| 300 mg OAD | q.d. | 2814 (39%) | 5.27 | 47882 (48%) |
Cmax and AUC are reported as geometric mean value, Tmax as median, and variability as %CV.
Abbreviations: AUC, area under the curve; Cmax, maximum concentration; IR, immediate release; OAD, once a day; PK, pharmacokinetic; Tmax, time to maximum concentration.
a
AUC is AUC0‐inf following s.d. administration and AUC0‐24h following q.d. dosing.