TABLE 1.
Assessments in ATS and CON
| CON (n = 14) | ATS (n = 14) | |||
|---|---|---|---|---|
|
| ||||
| Demographics | ||||
| Age (yrs) | 54 ± 15 | 54 ± 17 | ||
| Weight (lbs) | 162 ± 35 | 171 ± 42 | ||
| Height (inches) | 66 ± 4 | 66 ± 5 | ||
| Body mass index (kg/m2) | 26 ± 4 | 27 ± 4 | ||
| White | 14 | 13 | ||
| African American | 0 | 1 | ||
| Female | 9 | 9 | ||
| Functional Assessment of Cancer Therapy - Fatigue | 48 ± 3 | 46 ± 6 | ||
| Godin Physical Activity Questionnaire | ||||
| Days/weeks of strenuous activity | 3.8 ± 2.0 | 1.5 ± 1.9* | ||
| Days/weeks of moderate activity | 2.0 ± 1.8 | 3.4 ± 2.4 | ||
| Days/weeks of mild activity | 3.4 ± 3.0 | 3.5 ± 2.5 | ||
| Cardiopulmonary exercise testing | Rest | Peak Exercise | Rest | Peak Exercise |
| HR (beats/min) | 72 ± 9 | 163 ± 18 | 79 ± 10* | 170 ± 27 |
| Systolic blood pressure (mm Hg) | 126 ± 17 | 163 ± 20 | 122 ± 14 | 156 ± 13 |
| Diastolic blood pressure (mm Hg) | 82 ± 15 | 79 ± 12 | 81 ± 13 | 81 ± 15 |
| VO2 (ml/kg/min) | 3.7 ± 0.5 | 34.0 ± 10.3 | 3.5 ± 1.1 | 25.7 ± 7.0* |
| Respiratory exchange ratio | 0.79 ± .09 | 1.10 ± 0.10 | 0.82 ± .07 | 1.11 ± .06 |
| Minute ventilation (l/min) | 10.8 ± 4.2 | 88.9 ± 34.4 | 10.5 ± 4.0 | 67.9 ± 21.9* |
| Estimated peak metabolic equivalent | —— | 9.0 ± 3.0 | —— | 7.4 ± 2.0* |
| Magnetic resonance imaging | Pre-Exercise | Immediately Post-Exercise | Pre-Exercise | Immediately Post-Exercise |
| LVEDVi (ml/m2) | 76.3 ± 12.3 | 78.6 ± 15.7 | 69.9 ± 14.0 | 71.3 ± 16.0 |
| LVESVi (ml/m2) | 32.4 ± 7.3 | 26.1 ± 7.8 | 33.3 ± 8.5 | 27.9 ± 10.6 |
| SVi (ml/m2) | 43.8 ± 9.0 | 52.6 ± 12.3 | 36.5 ± 7.1* | 43.4 ± 11.7* |
| EF% | 57 ± 7 | 67 ± 9 | 53 ± 6 | 61 ± 9 |
| Qi (l/min/m2) | 2.7 ± 0.5 | 5.8 ± 1.5 | 2.3 ± 0.5* | 5.5 ± 1.6 |
Values are mean ± SD or n.
*
p < 0.05 difference between groups after adjusting for age, sex, and body mass index.
ATS = anthracycline-treated cancer survivors; CON = matched comparator subjects without cancer; LVEDVi = left ventricle end diastolic volume indexed for body surface area; LVESVi = left ventricle end systolic volume indexed for body surface area; Qi = cardiac output indexed for body surface area; SVi = left ventricular stroke volume indexed for body surface area; VO2 = oxygen consumption.