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. 2021 Dec 21;225(12):2056–2066. doi: 10.1093/infdis/jiab611

Figure 6.

Figure 6.

Seasonal inactivated influenza vaccine (SIIV) neutralizing geometric mean titers (GMTs) (A/H3N2/Singapore) and hemagglutination inhibition (HAI) GMTs (A/H3N2/Singapore, A/H1N1/Michigan, B/Colorado, B/Phuket) at 1 month after SIIV in participants aged 18–49 years (A) and 65–85 years (B) in the expanded cohort (evaluable influenza immunogenicity population). Total number of participants = 34–41 per group. Geometric mean ratios at 1 month after SIIV for bivalent respiratory syncytial virus prefusion F vaccine (RSVpreF) + SIIV to SIIV alone (ie, 1 month after placebo), to SIIV after RSVpreF, and to pooled SIIV after RSVpreF and SIIV alone are shown above each bar. Participants 18–49 years of age received quadrivalent SIIV containing A/H3N2/Singapore, A/H1N1/Michigan, B/Colorado, and B/Phuket; participants 65–85 years of age received high-dose trivalent SIIV containing A/H3N2/Singapore, A/H1N1/Michigan, and B/Colorado. Abbreviations: Al(OH)3, aluminum hydroxide; GMR, geometric mean ratio; GMT, geometric mean titer; HAI, hemagglutination inhibition; NT, neutralization titer; RSVpreF, bivalent respiratory syncytial virus prefusion F vaccine; SIIV, seasonal inactivated influenza vaccine.