Fig 7. A model for the effect of Saireito on leaky gut associated with antibiotic-induced dysbiosis.

The figure summarizes the results of this study. (A) Antibiotic therapy disturbs the normal gut microbiota. Pseudomonas spp., which is mostly occupied in the colon of mice treated with antibiotic, disrupts the intestinal epithelial barrier by decreasing the expression of TJPs and increasing epithelial cell apoptosis. (B) Saireito may suppress the growth of Pseudomonas spp., enhance the expression of TJPs and inhibit intestinal epithelial apoptosis, which contributes to alleviates leaky gut in antibiotic-treated mice.