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. 2022 Jun 3;18(6):e1010599. doi: 10.1371/journal.ppat.1010599

Fig 2. SAFA deficiency decreased the activation of antiviral immune genes.

Fig 2

(A) Models depicting the ChIP-seq assay of H3K27ac in Wild-type (WT) and SAFA−/− THP-1 cells with VSV infection for indicated hours. (B) Venn diagram showing amounts of enhancers in WT and SAFA−/− THP-1 cells with VSV infection. (C) GO term enrichment analysis of enhancers-related genes affected by SAFA depletion in ChIP -seq. (D) Delineation of -enhancers super based on H3K27Ac occupancy in WT and SAFA−/− THP-1 cells with VSV infection using the ROSE algorithm. (E) Line graph (RPKM) showing SAFA in regulation of VSV-induced and housekeeping supper-enhancer formation. (F) GO term enrichment analysis of super-enhancers related genes affected by SAFA depletion in ChIP -seq. (G) Genome browser views of ChIP -seq signal for the indicated genes. The cells were infected by VSV at 0.1 MOI. Data were pooled from two independent experiments (B-F). Data were representative of two independent experiments (G).