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. 2022 Jun 3;18(6):e1010599. doi: 10.1371/journal.ppat.1010599

Fig 5. RNA product interacted with SAFA mediated specific chromatin remodeling during viral infection.

Fig 5

(A) Models depicting the experiment design of knocking down RNA by CRISPR-Cas13d system and further detecting the chromatin accessibility with ATAC-qPCR after VSV infection. (B) Histogram showing the knockdown efficiency of crRNA of indicated RNAs after VSV infection for 18 hours. (C) ATAC-qPCR results showing the chromatin accessibility of indicated genes after the related RNA knockdown with or without VSV infection for 18 hours. Empty vector (EV) was used as control. *p < 0.05, **p < 0.01, ***p < 0.001 (Student’s t test, B and C). The cells were infected by VSV at 0.1 MOI. Data were pooled from three independent experiments (B and C). Error bars, SEM. n = 3 cultures.