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. 2022 Jun 1;13:847605. doi: 10.3389/fphar.2022.847605

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Copyright © 2022 Liu, Wang, Gu, Che, Wang, Cheng, Yuan, Cheng and Liao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KPT-8602 suppresses LPS-induced systemic inflammation. (A) C57BL/6 mice were given LPS (10 mg/kg) intraperitoneally after oral admiration of KPT-8602 (5 mg/kg) or vehicle (5 mice per group). (B) Representative photomicrographs of paraffin-embedded sections of the liver, lung, and kidney tissues stained with H&E. Scale bars, 250 μm for images, respectively. The expression levels of IL-1β, IL-6, and iNOS in the liver (C) and lung (D) were detected by real-time PCR. The expression of NLRP3, pro-caspase-1, pro-IL-1β, cleaved caspase-1, cleaved-IL-1β, and β-actin in the liver was analyzed by Western blotting (E), and the gray values of their bands were analyzed by using ImageJ and were normalized to β-actin (F). (^* indicates p < 0.05, ^** indicates p < 0.01, ^*** indicates p < 0.001, ^**** indicates p < 0.0001 by one-way ANOVA).