FIGURE 6.

KPT-8602 ameliorates PD model mice severity. C57BL/6 mice were treated with saline or MPTP (four i.p. injections of 20 mg/kg at 2 h intervals). KPT8602 (5 mg/kg) or vehicle were administered daily (7 mice per group). (A) Schedule of the PD model establishment and administration of KPT-8602. (B,C) Latency of the indicated mice on the rotarod. (D) Representative photomicrographs of tyrosine hydroxylase (TH)-stained sections from the substantia nigra compacta (SNc) of mice brain. Scale bars, 500 μm for images, respectively. (E) Number of TH-positive neurons was analyzed by ImageJ. The expression of TH and β-actin protein was analyzed by Western blotting (F), and the gray value of their bands in the SNc (G) and striatum (H) were analyzed by ImageJ. (^* indicates p < 0.05, ^** indicates p < 0.01 by one-way ANOVA).