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. 2022 Jun 15;5:586. doi: 10.1038/s42003-022-03530-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Polyamine depletion by DFMO decreases (a) OXPHOS and (b) glycolysis in male PHTs. Inhibition of spermine synthesis by SMS-silencing decreases (c) OXPHOS and (d) glycolysis in both male and female PHTs. Induction of SSAT-mediated polyamine catabolism by DENSPM decreases (e) OXPHOS and (f) glycolysis in both male and female PHTs. Bar graphs show mean ± SEM, N = 8–10 male PHTs and N = 8–10 female PHTs. OCR oxygen consumption rate; ECAR extracellular acidification rate; were measured on a Seahorse bioanalyzer.