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. 2022 Jun 15;5:586. doi: 10.1038/s42003-022-03530-6

Fig. 5. Polyamine depletion reduces acetyl-coA levels and decreases histone acetylation.

Fig. 5

In male PHTs, DFMO decreases a acetyl-coA levels as measured by LC-MS and b histone acetylation as determined by immunoblotting. c H3K27Ac abundance is decreased by DENSPM (DEN) and reversed by SAT1 silencing. d H3K27Ac abundance is decreased following SMS-silencing. Bar graphs show mean ± SEM, N = 8–10 male PHTs and N = 8–10 female PHTs.