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. 2022 Jun 15;13:3406. doi: 10.1038/s41467-022-30496-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Distribution of soft tissue and bone sarcoma subtypes among the cohort of 7494 patients. b Density curves showing age distributions for common pediatric, adolescent, and young adult (P-AYA; defined as ≤30 years of age) cancers. Vertical lines represent median age for each sarcoma. c Sankey diagram illustrating diagnostic corrections for 10.5% (789/7,494) of patient samples. Left, number of cases identified for each subtype according to original submitted pathology results; right, number of corrections or refinements for each histology as determined by the presence or absence of pathognomonic genomic rearrangements or signatures. NOS not otherwise specified, W/DD well or dedifferentiated, UPS undifferentiated pleomorphic sarcoma, MFH malignant fibrous histiocytoma, MPNST malignant peripheral nerve sheath tumor, UT ESS uterine endometrial stromal sarcoma, A alveolar, GIST gastrointestinal stromal tumor, DSRCT desmoplastic small round cell tumor, E embryonal, EM extraskeletal myxoid, IMT inflammatory myofibroblastic tumor, URC/EL undifferentiated round cell/Ewing-like, LGFMS/SEF low-grade fibromyxoid sarcoma/sclerosing epithelioid fibrosarcoma, EHE epithelioid hemangioendothelioma, DFSP dermatofibrosarcoma protuberans, PEComa perivascular epithelioid cell tumor, MES mesenchymal, P pleomorphic, ES extraskeletal, RMS rhabdomyosarcoma. Source data are provided as a Source Data file.