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. 2022 Jun 15;13:3406. doi: 10.1038/s41467-022-30496-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Heat map showing the frequency of recurrent short variants and copy number variants in the listed genes in each subtype of sarcoma, grouped as translocation-associated or genomically complex and other sarcomas (left), as well as the types of genomic alterations (right). b Volcano plot showing co-occurrence (odds ratio >1) and mutual exclusivity (odds ratio <1) between two genes within the same pathway. Top ten significant interactions (FDR < 0.05) are labeled. UT ESS uterine endometrial stromal sarcoma, ASPS alveolar soft part sarcoma, A alveolar, IMT inflammatory myofibroblastic tumor, LGFMS/SEF low-grade fibromyxoid sarcoma/sclerosing epithelioid fibrosarcoma, DSRCT desmoplastic small round cell tumor, URC/EL undifferentiated round cell/Ewing-like, DFSP dermatofibrosarcoma protuberans, EHE epithelioid hemangioendothelioma, UT uterine, P pleomorphic, UPS undifferentiated pleomorphic sarcoma, MFH malignant fibrous histiocytoma, ES extraskeletal, NOS not otherwise specified, PEComa perivascular epithelioid cell tumor, E embryonal, MPNST malignant peripheral nerve sheath tumor, W/DD well or dedifferentiated, GIST gastrointestinal stromal tumor. Source data are provided as a Source Data file.