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. 2022 Jun 15;13:3406. doi: 10.1038/s41467-022-30496-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Box-and-whisker plot of genomic loss of heterozygosity (gLOH) expressed as % of genome under LOH for each sarcoma histology. gLOH only evaluable n = 4619. Dashed horizontal line (19.3%) indicates 1 standard deviation above the mean gLOH. b Box-and-whisker plot of tumor mutational burden (TMB) and signatures derived from sequencing data for each sarcoma histology, grouped by age: pediatric, adolescent, and young adult (P-AYA) versus adult (>30 years). In (a, b), the lower and upper box boundaries represent 25th and 75th percentiles, lines within boxes represent medians, whiskers extend to extreme values ≤1.5 x IQR, and points beyond whiskers are outliers. Asterisk (*) indicates significant difference (with an FDR < 0.05) using a two-tailed non-parametric Mann–Whitney U test. In all cases, P-AYA harbored significantly lower TMB. c Relationship between tumor mutational burden (TMB) and genomic loss of heterozygosity (gLOH). Vertical line (10 mut/Mb) indicates distinction between “low” and “high” TMB. Dashed horizontal line (19.3%) indicates 1 standard deviation above the mean gLOH and indicates distinction between “low” and “high” gLOH. A alveolar, MES mesenchymal, DSRCT desmoplastic small round cell tumor, ASPS alveolar soft part sarcoma, URC/EL undifferentiated round cell/Ewing-like, LGFMS/SEF low-grade fibromyxoid sarcoma/ sclerosing epithelioid fibrosarcoma, DFSP dermatofibrosarcoma protuberans, OFT ossifying fibromyxoid tumor, EM extraskeletal myxoid, GIST gastrointestinal stromal tumor, E embryonal, W/DD well/dedifferentiated, EHE epithelioid hemangioendothelioma, RMS rhabdomyosarcoma, NOS not otherwise specified, UT uterine, ESS endometrial stromal sarcoma, IMT inflammatory myofibroblastic tumor, GCTB giant cell tumor of bone, PEComa perivascular epithelioid cell tumor, MPNST malignant peripheral nerve sheath tumor, P pleomorphic, ES extraskeletal, UPS undifferentiated pleomorphic sarcoma, MFH malignant fibrous histiocytoma. Source data are provided as a Source Data file.