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. 2022 Jun 15;13:3406. doi: 10.1038/s41467-022-30496-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Dominant mutational signatures in various sarcoma histologies. b Evidence for clinical actionability of somatic alterations across 44 sarcoma histologies. SOC, standard of care. c Flow chart of actions taken as a result of comprehensive genomic sequencing in 118 patients at MSK who underwent Foundation Medicine sequencing. OncoKB classifications were not applied retrospectively for the MSK cohort and thus reflect prevailing knowledge at time of enrollment. APOBEC, apolipoprotein B mRNA editing catalytic polypeptide-like; MMR, mismatch repair deficiency. Tobacco signifies mutational genomic signature attributable to cancers derived from tissues potentially exposed to tobacco smoke. UPS undifferentiated pleomorphic sarcoma, MFH malignant fibrous histiocytoma, MPNST malignant peripheral nerve sheath tumor, NOS not otherwise specified, PEComa perivascular epithelioid cell tumor, IMT inflammatory myofibroblastic tumor, E embryonal, DSRCT desmoplastic small round cell tumor, GIST gastrointestinal stromal tumor, ESS endometrial stromal sarcoma, W/DD well or dedifferentiated, P pleomorphic, ES extraskeletal, DFSP dermatofibrosarcoma protuberans, MES mesenchymal, LGFMS/SEF low-grade fibromyxoid sarcoma/sclerosing epithelioid fibrosarcoma, URC undifferentiated round cell, EHE epithelioid hemangioendothelioma, A alveolar, EM extraskeletal myxoid. Source data are provided as a Source Data file.