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. 2022 Jun 15;13:3405. doi: 10.1038/s41467-022-30453-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Alteration type and frequency, fraction of genome altered (FGA) and tumor mutation burden (TMB) by subtype. Oncogenic fusions detected by MSK-IMPACT are classified as drivers. In the FGA and TMB plots, box boundaries indicate 25th and 75th percentiles, interior lines medians, and whiskers 1.5 times the interquartile range. VUS variant of unknown significance. B Significant mutations were identified in all subtypes with n ≥ 20 in our dataset using both MutSig and MuSiC analysis. Percentages indicate the percentage of samples with an oncogenic mutation in the corresponding gene. C FLT4 mutation type, frequency, and location in ANGS vs. other subtypes. D Cancer cell fraction (CCF) and number of mutations for driver mutations and VUS by subtype. Circles indicate medians and vertical lines interquartile ranges.