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. 2022 Jun 15;13:3405. doi: 10.1038/s41467-022-30453-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Copy number alteration (CNA) and whole-genome doubling events (WGD) compared across subtypes. A Individual sample CNA across the genome for each subtype. WGD, fraction genome altered (FGA), and purity are shown at right. B Aggregate arm-level (left) and gene-level events (right) grouped by subtype. *significant change based on Bonferroni corrected p-values. Significance was evaluated by random permutations testing. Oncogenic (bold) vs. non-oncogenic CNA classifications according to OncoKB. C Frequency of WGD by subtype (green) compared to other cancers with ≥200 samples available for comparison (gray)¹³. NSCLC, non-small cell lung cancer; ST, soft tissue. D, Overall survival based on WGD status within primary and metastatic samples. p.adj, adjusted p-value.