Fig. 5. Mutual exclusivity, co-occurrence, ATRX alterations, and unsupervised clustering based on genetic signatures.

A Co-occurrence and mutual exclusivity of gene- (top) and pathway-level (bottom) alterations in each subtype with significant findings shown. Significance was evaluated by two-sided Fisher’s exact test. EPI, epigenetic; DDR, DNA damage repair. B Frequency and types of oncogenic ATRX alterations in each of the 14 most altered subtypes. C Unsupervised clustering of all samples based on oncogenic alteration patterns. D Subtype-specific cluster associations and entropy scores. For clarity, subtypes with n > 5 are displayed.