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. 2022 Jun 15;12:9951. doi: 10.1038/s41598-022-14197-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Chemotherapy drugs and target therapy drugs reduced the tumor xenograft area of hTERT cells. (A) The tumor area of T0 and T3 drug-treated and solvent-treated groups was measured with Noldus DanioScopeTM software. (B) A representative image is shown. Control-T0, time point at injection (control embryos at 48 hpf); Control-T3, time point 3 days later in fish water with solvent alone (untreated embryos at 120 hpf); Control-T3+ drugs, time point 3 days later in fish water with drugs (treated embryos at 120 hpf). The experiments were performed twice and each group was representative of 25 embryos. Data are shown as mean ± SEM [****p < 0.0001; **p < 0.01; *p < 0.05].