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. 2022 Jun 15;12:9951. doi: 10.1038/s41598-022-14197-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Vorinostat enhanced the effect of the chemotherapy drugs on hTERT cell viability. (A) Concentration–response curves of cisplatin− and cisplatin plus vorinostat-induced inhibition of cell viability. Cells were treated with increasing concentrations of cisplatin alone or in combination with vorinostat at fixed concentration molar ratio (cisplatin:vorinostat = 2.9:1) for 4 days. (B) Concentration–response curves of doxorubicin− and doxorubicin plus vorinostat-induced inhibition of cell viability. Cells were treated with increasing concentrations of doxorubicin alone or in combination with vorinostat at fixed concentration molar ratio (doxorubicin: vorinostat = 1:62.7) for 4 days. Cell viability was evaluated by MTT assay. Data are shown as mean ± SEM. (C,D) Semilogarithmic-Combination Index Plot of combined treatments with cisplatin plus vorinostat and doxorubicin plus vorinostat respectively. Dose and effect data obtained were converted to Fa values and analyzed with CompuSyn software [*p < 0.0001; ^#p < 0.01; ^§p < 0.05].